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Serum or plasma concentration of brain-derived neurotrophic factor (BDNF) measured by immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of brain-derived neurotrophic factor (BDNF) in your blood. BDNF is a protein that supports the growth and health of nerve cells in the brain and nervous system.

Quick summary

["BDNF helps maintain brain function and may be linked to mood, memory, and nerve health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
37218-5
Short code
MR Brain.temporal
Synonyms
MR Brain.temporal
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Brain-Derived Neurotrophic Factor (BDNF)?

BDNF, or brain-derived neurotrophic factor, is a protein produced by cells in the brain and nervous system. It plays a key role in supporting nerve cell growth, survival, and function. Levels of BDNF can vary based on health, stress, physical activity, and certain medical conditions.

Why Might You Need This Test?

Your healthcare provider may order a BDNF test to evaluate symptoms such as depression, anxiety, memory issues, or nerve-related problems. It may also be used in research or clinical studies investigating brain health, mood disorders, or neurodegenerative conditions.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The blood is then processed to separate serum or plasma, which is sent to a lab for analysis using an immunoassay method to measure BDNF levels.

What Do Results Mean?

Results provide a quantitative measure of BDNF concentration in your blood. While reference ranges can vary by lab, they help identify whether your levels are above, below, or within expected ranges. Interpretation depends on clinical context, such as your symptoms or medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

BDNF Level

Frequently asked questions

Why was this test ordered?
Your doctor may have linked your symptoms—such as mood changes, memory problems, or nerve discomfort—to potential BDNF imbalances. BDNF is also studied in conditions like depression, Alzheimer’s disease, or nerve injuries, so results may guide treatment decisions or further testing.
What are typical reference ranges?
Reference ranges for BDNF can differ by lab, but they often fall in the range of approximately 10–100 pg/mL (picograms per milliliter). Your actual results will be compared to your lab’s specific standards, and your doctor will discuss what they mean for you.
Can lifestyle changes affect BDNF levels?
Yes! Physical activity, diet, stress management, and sleep can influence BDNF levels. Regular exercise, a balanced diet, and reducing stress may help support healthy nerve function and potentially improve BDNF levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy