Skip to content

Serum or plasma mass concentration of total bilirubin

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin in your blood, a yellow pigment produced when red blood cells break down. It helps assess liver function and detect conditions like jaundice or bile duct blockages.

Quick summary

["Total bilirubin levels can signal liver or bile problems, including jaundice or gallbladder issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46299-4
Short code
MR Brst-Ul
Synonyms
MR Brst-Ul
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for liver problems, such as hepatitis, cirrhosis, or bile duct blockages. It can also help diagnose conditions like Gilbert’s syndrome, hemolytic anemia, or certain genetic disorders. Sometimes, it’s used to monitor treatment progress for liver diseases.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into your arm to draw a blood sample. If you’re fasting, follow your doctor’s instructions to ensure accurate results.

What the Results Mean

Higher than normal levels may indicate liver disease, red blood cell breakdown, or other conditions affecting bile flow. Lower levels are less common but could signal certain liver or metabolic issues. Your doctor will interpret results in the context of your overall health.

Common Conditions This Test Helps Diagnose

This test is often used to identify liver diseases (like hepatitis or cirrhosis), bile duct obstructions, hemolytic anemia (where red blood cells break down too quickly), or genetic disorders like Crigler-Najjar syndrome. It can also help monitor jaundice in newborns.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Total bilirubin is a key marker for liver function and bile flow. Elevated levels often point to conditions that require further investigation, such as liver inflammation, blockages, or red blood cell destruction. Low levels are less frequently abnormal but may warrant evaluation for rare metabolic or genetic causes.

Short name

Total bilirubin

Frequently asked questions

What causes total bilirubin levels to be higher than usual?
Higher bilirubin levels can result from liver problems (like inflammation or disease), blockages in the bile ducts, or when red blood cells break down faster than the liver can process bilirubin. Conditions such as hepatitis, gallstones, or certain genetic disorders may also play a role.
How long does it take to get results from this test?
Results from a total bilirubin test are typically available within a few days to a week, depending on your lab’s processing time. Your doctor will contact you once they have the results to discuss them further.
Can diet or medications affect total bilirubin levels?
While diet alone usually doesn’t significantly alter bilirubin levels, certain medications (like some antibiotics or anti-inflammatory drugs) may influence liver function indirectly. Always inform your doctor about all medications or supplements you’re taking before the test.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy