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Cerebrospinal Fluid (CSF) Protein Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Proteins in CSF can help identify conditions affecting your nervous system.

Quick summary

["Protein levels in CSF may signal inflammation, infection, or structural issues in the brain or spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30655-5
Short code
MR Cerebral cist
Synonyms
MR Cerebral cist
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues that suggest problems like meningitis, multiple sclerosis, or brain tumors. It’s also used to monitor conditions like Guillain-Barré syndrome or spinal cord injuries.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your spinal column (lumbar puncture) to collect CSF. It may cause temporary soreness or mild discomfort, but you’ll be able to go home the same day.

What the Results Mean

Normal protein levels in CSF are usually lower than in blood. Elevated levels can indicate inflammation, infection, or blood leakage into the CSF. Very high levels may suggest tumors or severe neurological diseases. Your doctor will interpret results in the context of your symptoms and medical history.

Common Conditions Affecting CSF Protein Levels

Conditions like multiple sclerosis, meningitis, or brain tumors can cause abnormal protein levels. Other factors, such as aging or certain medications, may also influence results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Level

Frequently asked questions

How often will I need this test?
Your doctor will determine how often you need this test based on your condition. Some patients may need it once, while others may require follow-up tests every few months or years.
Will I feel any pain during or after the test?
You may feel a slight pinch during the needle insertion, but most people describe it as mild. Afterward, you might experience mild soreness or stiffness in your lower back for a day or two. Rest and staying hydrated can help.
Can I drink or eat before the test?
You can eat and drink normally before the test unless your doctor advises otherwise. No fasting is required.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy