Metabolite profile of cerebrospinal fluid (CSF) using high-performance liquid chromatography (HPLC)

What Does This Test Measure?

The test identifies specific metabolites, including amino acids, organic acids, and other small biochemical compounds in your cerebrospinal fluid. These substances play roles in brain function, energy production, and waste removal. Abnormal levels may indicate issues like metabolic disorders, infections, or neurological conditions.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like headaches, neurological deficits, or suspected metabolic disorders. It’s also used in research or specialized diagnostic scenarios where detailed CSF chemistry is needed.

How Is the Sample Collected?

A small amount of cerebrospinal fluid is collected via a procedure called lumbar puncture (spinal tap). A needle is inserted into your lower back to draw the fluid into a sterile container. This is typically done in a hospital setting under sterile conditions.

What Are Common Conditions Monitored?

This test can help evaluate conditions like meningitis, encephalitis, metabolic disorders (e.g., organic acidemias), or rare neurological diseases affecting CSF chemistry. It may also support research into brain chemistry or developmental disorders.