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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes important proteins like albumin and globulins that help maintain fluid balance and support immune function.

Quick summary

["Your blood protein levels can signal health issues like dehydration, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36091-7
Short code
MR Hrt Ltd
Synonyms
MR Hrt Ltd
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Blood proteins play key roles in your body’s health. High or low levels may indicate conditions like malnutrition, infections, or organ damage. Your doctor may order this test to check for these issues or monitor existing conditions.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm, and a blood sample will be drawn. It usually takes a few minutes. If you’re on blood thinners, let your doctor know before the test.

Common Reasons for Testing

Doctors often check total protein levels when evaluating symptoms like swelling, unexplained weight loss, fatigue, or signs of infection. It may also be used to monitor chronic conditions like kidney disease or liver disorders.

What the Results Mean

Results are compared to a general range for your age and health. Very high or very low levels can raise concerns, but individual results depend on your overall health. Your doctor will discuss these with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated protein levels may suggest conditions like multiple myeloma, severe dehydration, or liver disease. Low levels could indicate malnutrition, kidney disease, or liver problems. Always review results with your healthcare provider, as they consider your full medical picture.

Short name

Total Protein

Frequently asked questions

What causes protein levels to be too high?
High protein levels can result from conditions like multiple myeloma (a blood cancer), severe dehydration, or certain liver or kidney diseases. Chronic inflammation or infections may also contribute. Your doctor will investigate further if needed.
What causes protein levels to be too low?
Low protein levels often occur due to malnutrition, kidney disease, liver problems, or certain infections. Severe burns or rapid weight loss can also lead to low protein. Your doctor may recommend dietary changes or other treatments if necessary.
How often should I get this test?
Your doctor will determine how often you need this test based on your health status, symptoms, and any ongoing conditions. Regular monitoring may be needed if you have chronic diseases like kidney or liver problems.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy