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Alpha-1 Antitrypsin (A1AT) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and other chronic conditions linked to low protein levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35956-2
Short code
MR IAC
Synonyms
MR IAC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order an Alpha-1 Antitrypsin test if you have symptoms of lung disease (such as chronic bronchitis or emphysema), liver problems, or a family history of Alpha-1 Antitrypsin deficiency. It can also be checked during routine evaluations for certain genetic conditions.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm, typically in a lab setting. If you’re concerned about needles, let your healthcare provider know.

What the Results Mean

Lower than normal levels may indicate Alpha-1 Antitrypsin deficiency, which can increase your risk of lung disease or liver issues. Higher levels may be seen in certain liver diseases or infections.

Common Causes of Abnormal Results

Abnormal results can occur due to genetic mutations, liver disease, or other inflammatory conditions. Your doctor will discuss findings in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Alpha-1 Antitrypsin deficiency is an inherited condition that can lead to chronic lung diseases like emphysema or chronic obstructive pulmonary disease (COPD). Low levels may also affect the liver, though this is less common. Regular monitoring is important for those at risk.

Short name

Alpha-1 Antitrypsin

Frequently asked questions

What triggers this test?
Symptoms like persistent coughing, shortness of breath, or unexplained liver issues, or if you have a family history of Alpha-1 Antitrypsin deficiency.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times.
Can diet or exercise affect this test?
Dietary changes or exercise alone usually don’t impact Alpha-1 Antitrypsin levels, but certain medications (like liver disease treatments) may. Always discuss with your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy