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Serum or plasma mass concentration of total protein (measured by electrophoresis)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Total protein levels can signal health issues like dehydration, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35980-2
Short code
MR LE-R
Synonyms
MR LE-R
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions affecting protein levels, such as kidney disease (where proteins may leak into urine), liver disease (where protein production is impaired), or dehydration (which can raise protein concentration). It’s also used in diagnosing or monitoring certain medical conditions like multiple myeloma or severe infections.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Results are compared to a general reference range for healthy adults. Low levels might indicate malnutrition, kidney disease, or liver problems, while high levels could suggest dehydration, inflammation, or certain cancers.

Common Conditions Affecting Results

Conditions like kidney disease, liver disease, infections, or severe burns can alter protein levels. Hormonal imbalances, pregnancy, or certain medications may also impact results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein (Electrophoresis)

Frequently asked questions

What does a low total protein level mean?
A low total protein level may signal conditions like malnutrition, chronic kidney disease, or liver dysfunction. Your provider will review your symptoms and other test results to determine the cause.
How often should I get this test?
Frequency depends on your health status. If you have a chronic condition like kidney or liver disease, your provider may recommend regular monitoring. Otherwise, this test is often done as needed for diagnosis or follow-up.
Can diet affect protein test results?
Yes, diet can influence protein levels. Eating a balanced diet with adequate protein may help maintain normal levels, but extreme dietary changes (like very low-protein diets) could temporarily affect results. Always follow your provider’s advice.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy