Liver and Pancreas Function Panel (Serum-Based)

This test measures specific substances in your body, such as cells, chemicals, proteins, or hormones, giving your healthcare provider a clear picture of how well certain organs and body systems are working.

Your blood sample will be analyzed for several markers, including enzymes and proteins that reflect liver and pancreas health. These may include alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and pancreatic enzymes like amylase or lipase, depending on the specific panel ordered. Some panels may also measure bilirubin or albumin.

Your provider may order this test as part of a routine checkup, to help diagnose a medical condition, to monitor an ongoing health problem, or to check how well a current treatment is working over time.

Doctors may recommend this test if you have symptoms like jaundice (yellowing skin), unexplained fatigue, abdominal pain, or if you have a history of liver or pancreas conditions (e.g., hepatitis, pancreatitis, or cirrhosis). It can also be used during routine check-ups or before certain treatments.

Abnormal results may be linked to symptoms such as unusual fatigue, unexplained weight changes, fever, persistent pain, weakness, dizziness, or changes in appetite, although some conditions cause no noticeable symptoms at all.

High levels of certain enzymes (like ALT, AST, or ALP) may indicate liver damage, while elevated pancreatic enzymes (like amylase or lipase) could signal pancreatitis. Other findings might suggest bile duct blockages or chronic liver disease.

Before the test, your healthcare provider will give you specific instructions, which may include fasting for a set number of hours, avoiding certain medications or supplements, and staying hydrated, so be sure to share all medications you take and any allergies you have.

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if certain enzymes are being measured. Avoid alcohol and certain medications (like pain relievers) for 24 hours beforehand if instructed by your doctor.