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Serum or plasma concentration of mineralocorticoid-binding globulin (MCBG)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a protein in your blood that helps regulate hormones involved in fluid balance and blood pressure.

Quick summary

["MCBG helps assess how well your body processes certain hormones linked to kidney function and mineral balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
24968-0
Short code
MR L-spine
Synonyms
MR L-spine
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if they suspect conditions affecting hormone binding, such as kidney disease, liver issues, or certain hormone-related disorders. It can also be part of broader evaluations for conditions like primary aldosteronism or Cushing’s syndrome.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours before the draw if your blood is collected in the morning. Avoid excessive alcohol or certain medications that could affect hormone levels for 24 hours prior.

How the Test Works

A small blood sample is taken from a vein in your arm. The sample is then analyzed to measure the concentration of MCBG protein in your serum or plasma.

What the Results Mean

Results help identify if your hormone levels are being affected by how MCBG binds to them. Abnormal levels may indicate underlying health issues that need further medical evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: MCBG plays a role in transporting hormones like aldosterone and cortisol. Low levels may suggest conditions like hypoaldosteronism or liver dysfunction, while high levels could be linked to kidney problems or certain genetic disorders.

Short name

MCBG Level

Frequently asked questions

What causes an abnormal MCBG test result?
Abnormal results may be due to conditions affecting the liver, kidneys, or hormone systems, such as cirrhosis, chronic kidney disease, or genetic disorders like congenital adrenal hyperplasia.
How long does it take to get the results?
Results are typically available within 1 to 3 business days, depending on your lab’s processing time.
Can diet or medications affect this test?
Certain medications (e.g., steroids, diuretics) or dietary changes (e.g., high salt intake) may influence hormone levels indirectly, so your doctor may advise avoiding them for 24 hours before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy