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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum, which helps assess overall protein levels and kidney function.

Quick summary

["Total protein levels can indicate kidney health and protein loss in urine or other conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36780-5
Short code
MR Toe
Synonyms
MR Toe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for kidney disease, liver problems, malnutrition, or conditions causing protein loss (such as nephrotic syndrome). It can also help monitor chronic conditions like heart failure or certain autoimmune diseases.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your lab requires it, but this is rare for protein tests. Bring any medications or supplements you’re taking.

How the Test Works

A blood sample is drawn from a vein in your arm. The blood is then separated into serum (the liquid part after clotting) for testing. The protein content is measured using a standard laboratory method, often automated and precise.

Possible Results and Interpretation

Results are typically reported in grams per deciliter (g/dL). Low levels may suggest malnutrition, liver disease, or kidney problems, while very high levels could indicate dehydration, inflammation, or conditions like multiple myeloma.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What Does This Test Tell Your Doctor?
Your doctor may use total protein levels to diagnose or monitor conditions like kidney disease (e.g., chronic kidney disease), liver disorders (e.g., cirrhosis), or protein-losing syndromes. It can also help assess nutritional status or detect hidden protein loss in urine (proteinuria).
How Often Should I Get This Test?
The frequency depends on your health condition. For example, people with kidney disease may need this test every few months, while healthy individuals may only get it if they have risk factors (e.g., diabetes, high blood pressure). Always follow your doctor’s recommendations.
Can I Eat or Drink Before the Test?
Most protein tests don’t require fasting, but check with your lab or doctor. Avoid excessive alcohol or high-protein foods 24 hours before if instructed. Hydration is fine unless your doctor specifies otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy