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Synovial Fluid Alpha-1 Antitrypsin (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of alpha-1 antitrypsin in your joint fluid, which helps assess inflammation or damage in joints affected by conditions like rheumatoid arthritis or other inflammatory joint diseases.

Quick summary

["Alpha-1 antitrypsin in synovial fluid can indicate joint inflammation or cartilage breakdown."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
15489-8
Short code
M synoviae Ab Ser Ql IA
Synonyms
M synoviae Ab Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like joint pain, swelling, or stiffness, especially if you have a known history of inflammatory joint diseases. It can also be used to monitor disease activity or guide treatment decisions in certain conditions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into one of your joints to collect the synovial fluid. This is usually done in a doctor’s office or clinic and is typically quick and well-tolerated.

What the Results Mean

Lower than expected levels of alpha-1 antitrypsin in synovial fluid may suggest increased inflammation or tissue breakdown in your joints. Higher levels could indicate less inflammation or other underlying conditions. Your results will be interpreted by your healthcare provider in the context of your overall health and symptoms.

Common Conditions Monitored

This test is often used to monitor rheumatoid arthritis, osteoarthritis with inflammation, or other inflammatory joint diseases. It can help track disease progression or response to treatment by assessing joint fluid for signs of inflammation or damage.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin in Synovial Fluid

Frequently asked questions

How Often Will I Need This Test?
The frequency depends on your condition and treatment plan. Your healthcare provider will determine how often you need this test based on your symptoms, medical history, and responses to treatment.
What Are Normal Results?
There are no standard reference ranges provided here since they can vary by lab and patient. Your results will be compared to your specific lab’s reference values and interpreted by your healthcare provider.
Can I Do Anything to Prepare for This Test?
No special preparation is required. However, inform your healthcare provider about any medications you’re taking, especially blood thinners, as they may affect the procedure.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy