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Serum or plasma concentration of total bilirubin (qualitative or screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin, a yellow pigment produced when red blood cells break down. Bilirubin is a key part of your body’s natural recycling process for old blood cells.

Quick summary

["Bilirubin helps identify liver function, bile flow, and red blood cell health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55224-0
Short code
M tb A60 Ab Ser Ql IA
Synonyms
M tb A60 Ab Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like jaundice (yellowing of skin/eyes), unexplained fatigue, dark urine, pale stools, or if they suspect liver disease, bile duct issues, or hemolytic anemia (red blood cell breakdown). It can also be part of routine liver function checks.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a different method for accuracy. Wear a loose shirt for easy access.

How the Test Works

A healthcare provider will collect a blood sample from your arm. The sample is sent to the lab, where bilirubin levels are measured using a colorimetric or immunoassay method to determine total concentration.

What the Results Mean

Results are qualitative (qualitative screening) or interpreted as a screening value. High levels may indicate liver disease, blockages in bile ducts, or red blood cell disorders. Low levels are less common but could signal liver dysfunction or certain genetic conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Bilirubin Level (Serum/Plasma)

Frequently asked questions

What does elevated bilirubin mean?
Elevated bilirubin often signals jaundice or liver/bile duct problems. Common causes include hepatitis, cirrhosis, gallstones, or hemolytic anemia. Your doctor will discuss next steps based on your symptoms and other test results.
What if my bilirubin is low?
Low bilirubin is rare but may occur with liver disease (e.g., severe hepatitis) or certain genetic disorders. Your doctor will investigate further if this is unexpected, especially if you have other symptoms like fatigue or weight loss.
How often should I get this test?
Frequency depends on your health. Routine adults may not need it unless they have liver-related conditions. Follow-up may be scheduled if you have chronic liver issues, recent infections, or other risk factors.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy