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Mycobacterium tuberculosis complex (MTB) whole-genome sequencing for nucleic acid detection (probe-based)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from *Mycobacterium tuberculosis*, the bacterium responsible for tuberculosis (TB). It helps determine if you have an active TB infection by analyzing a sample from your respiratory tract.

Quick summary

["A positive result may indicate TB infection, guiding treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
85362-2
Short code
M TB Cmplx DNA Spt/Bro Ql NAA+probe
Synonyms
M TB Cmplx DNA Spt/Bro Ql NAA+probe
Category
chemistry
Sample
sputum
Container
Sterile sputum container
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
85610
SNOMED
396252006
Specimen volume
3-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
TAT
4–24 hours
Order
routine

How the Test Works

The test extracts genetic material (DNA) from your sample, which is then analyzed using a specialized probe to detect the presence of *Mycobacterium tuberculosis* genes. This method is highly sensitive and specific for identifying TB infection.

Sample Collection

You’ll provide a respiratory sample, such as a sputum or induced sputum sample, depending on your healthcare provider’s instructions. This sample is collected to capture bacteria that may be present in your lungs or airways.

What to Expect Before the Test

No special preparation is usually needed, but your provider may ask you to avoid certain medications or follow specific breathing techniques to increase sample quality. Follow their guidance closely.

Possible Results

A positive result means the test found genetic material from *Mycobacterium tuberculosis*, suggesting an active TB infection. A negative result means the test did not detect the bacterium’s genetic material, but further testing may still be needed.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: sputum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing TB, especially in cases where traditional culture methods take longer. Early detection allows for prompt treatment, reducing the risk of spreading TB to others and preventing complications.

Short name

MTB Genomic Probe Test

Frequently asked questions

Why was I asked to take this test?
Your healthcare provider may recommend this test if you have symptoms of TB (such as persistent cough, fever, or weight loss), a history of TB exposure, or if you live in an area with higher TB rates. It helps confirm or rule out infection before starting treatment.
What does a positive result mean?
A positive result strongly suggests an active TB infection. Your provider will work with you to determine the next steps, including starting appropriate antibiotics to treat the infection.
Can I get TB from this test?
No, this test does not expose you or healthcare workers to TB. The sample is processed in a way that prevents the live bacterium from escaping, ensuring safety for everyone involved.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy