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Mycobacterium tuberculosis complex RNA, qualitative nucleic acid amplification test (specimen: respiratory sample)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from *Mycobacterium tuberculosis* (TB bacteria) in a sample from your respiratory tract, such as sputum or induced sputum. It helps determine if you may have active TB infection.

Quick summary

["A quick way to screen for TB bacteria in your lungs or airways."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48174-7
Short code
M TB Cmplx rRNA Spec Ql NAA+probe
Synonyms
M TB Cmplx rRNA Spec Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a specialized probe to detect RNA from TB bacteria. If TB bacteria are present, their genetic material will react with the probe, triggering a positive result. This method is highly sensitive and can detect TB even when traditional tests may not.

What to Expect Before the Test

No special preparation is needed. You may be asked to provide a sample of sputum (phlegm) after coughing deeply into a container, or you might have a procedure to induce sputum production if needed. If you have a respiratory condition, your healthcare provider may guide you on how to prepare.

What to Expect During the Test

The test is typically done in a lab setting. You’ll provide a sample (like sputum), which is then processed and analyzed using a molecular technique. Results are usually available within a few days.

Possible Results and Next Steps

A positive result means the test detected TB RNA, suggesting you may have an active TB infection. A negative result means no TB RNA was found in the sample. Follow-up testing or further evaluation by a healthcare provider may be needed based on your symptoms and clinical picture.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

TB RNA Test (Screen)

Frequently asked questions

What does a positive result mean?
A positive result indicates that the test detected genetic material from TB bacteria in your respiratory sample. This suggests you may have an active TB infection, and your healthcare provider will likely recommend further testing and treatment to manage the infection.
Can I get TB from this test?
No, the test itself does not expose you to TB bacteria. The sample is processed in a lab setting with strict safety protocols to prevent contamination. You should not be at risk of infection from the test procedure.
How accurate is this test?
This test is highly accurate for detecting TB bacteria in respiratory samples. It is considered one of the most sensitive and specific methods available for TB screening, though results should be interpreted by a healthcare provider in the context of your symptoms and medical history.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy