Skip to content

Mycobacterium tuberculosis Complex (M. tuberculosis, M. bovis, M. canettii, etc.) by Nucleic Acid Amplification Probe (NAAT) Test

Published: August 9, 2026Updated: August 16, 2026

This test detects genetic material from certain bacteria that cause tuberculosis (TB) using a specialized molecular probe. It helps identify if you have an active TB infection.

Quick summary

["A quick, accurate way to check for TB bacteria in respiratory samples, even when other tests are inconclusive."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94576-6
Short code
MTB complex sp Islt NAA+probe
Synonyms
MTB complex sp Islt NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a small sample of your respiratory secretions (like sputum or induced sputum) to extract genetic material. A probe detects specific DNA sequences unique to Mycobacterium tuberculosis complex bacteria. If present, the test confirms possible TB infection.

Sample Collection

You’ll likely provide a sputum sample (from coughing) or an induced sample (using a machine to stimulate coughing). Some facilities may use nasal swabs for children or those who can’t produce sputum.

Test Results Interpretation

A positive result means the test detected TB bacteria DNA, suggesting a possible TB infection. A negative result means no TB bacteria DNA was found in the sample. Results should be reviewed by a healthcare provider for clinical correlation.

When This Test Is Used

Doctors may order this test if you have symptoms like coughing, fever, or weight loss, especially if you live in or traveled to areas with higher TB rates. It’s also used for initial screening or when other tests are unclear.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

M. tuberculosis NAAT Probe Test

Frequently asked questions

Why is this test important?
This test is critical for early diagnosis of TB, which can be life-threatening if untreated. It helps healthcare providers start appropriate treatment quickly, including antibiotics, and prevents spread of the infection.
FAQ 1
This test is not the same as a TB skin test (like the Mantoux test). The NAAT probe test detects bacteria DNA directly, while skin tests measure immune response.
FAQ 2
Yes, the test can be done on samples from other body sites (like urine or blood) if TB is suspected in those areas, but respiratory samples are most common for standard TB testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy