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Mitochondrial DNA (mtDNA) Quantitative Analysis by Probe-Based Assay (Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of mitochondrial DNA (mtDNA) in your blood plasma using a specialized genetic probe. It helps assess mitochondrial function and may be used to evaluate conditions affecting mitochondrial health.

Quick summary

["This test checks for genetic markers related to mitochondrial health in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14562-3
Short code
M tb DNA Smn Ql NAA+probe
Synonyms
M tb DNA Smn Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or risk factors linked to mitochondrial disorders, such as chronic fatigue, muscle weakness, or neurological issues. It can also be part of a broader evaluation for genetic conditions or research studies involving mitochondrial genetics.

How the Test Works

A small blood sample is taken to collect plasma. The mtDNA is extracted and analyzed using a genetic probe to determine its concentration relative to nuclear DNA. This process helps identify variations in mitochondrial DNA that may influence health.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast or avoid certain medications for 12 hours before the test. Always follow your provider’s instructions.

What to Expect During the Test

You’ll have a simple blood draw, similar to a routine lab test. The process takes about 5 minutes, and you may feel a slight pinch. The plasma is then processed in a lab for genetic analysis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

mtDNA Plasma Probe Test

Frequently asked questions

What Does a Low or High mtDNA Level Mean?
A low mtDNA level may signal mitochondrial dysfunction, which could be linked to conditions like mitochondrial myopathy or other metabolic disorders. A high level might be seen in certain genetic conditions or as part of normal aging, but further evaluation is needed to interpret results accurately.
How Often Should This Test Be Done?
The frequency depends on your clinical situation. If you’re undergoing monitoring for a known mitochondrial disorder, your provider may recommend periodic testing. For research or general screening, it may not be routinely repeated unless symptoms change or new findings arise.
Is This Test Covered by Insurance?
Coverage depends on your insurance plan and clinical indication. If ordered for a specific diagnosis or research purpose, check with your insurance provider or healthcare team to confirm coverage details.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy