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Myeloperoxidase (MPO) Antibody Screening in Whole Blood by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against myeloperoxidase, an enzyme found in white blood cells. It helps identify certain autoimmune conditions or infections.

Quick summary

["This screening helps detect immune responses linked to inflammation or autoimmune diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46217-6
Short code
M TB IFN-g CD4+ T-cells Bld-aCnc
Synonyms
M TB IFN-g CD4+ T-cells Bld-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like joint pain, unexplained fevers, or signs of an inflammatory condition. It could also be part of a broader evaluation for autoimmune disorders or suspected infections.

What to Expect Before the Test

No special preparation is needed. You’ll provide a small blood sample drawn from your arm. The test is typically done in a lab setting and may take a few minutes.

What the Results Mean

Results are qualitative (positive or negative). A positive result suggests the presence of antibodies against myeloperoxidase, which may indicate an immune response. Your doctor will interpret results in the context of your symptoms and medical history.

Common Conditions Linked to Positive Results

Positive results may be associated with autoimmune diseases like systemic lupus erythematosus (SLE) or other inflammatory conditions. It can also appear in infections or during periods of high immune activity.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: This test is primarily used as a screening tool. Elevated antibody levels can signal an immune response but do not diagnose a specific condition alone. Doctors often use these results alongside other tests and clinical findings to guide further evaluation.

Short name

MPO Antibody Screen

Frequently asked questions

What does a positive result mean for my health?
A positive result means your body has detected antibodies against myeloperoxidase, which could indicate an immune response. This may raise suspicion for autoimmune conditions or infections, but further testing and evaluation are needed to determine the exact cause.
Can I eat or drink before this test?
No special diet or fasting is required for this blood test. You can eat and drink normally as usual.
How long will I need to wait for my results?
Results are usually available within a few days to a week, depending on lab processing times. Your doctor will contact you with the final interpretation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy