Myeloperoxidase (MPO) Antibody, Serum (Quantitative)
This blood test measures the level of antibodies against myeloperoxidase, an enzyme found in white blood cells. It may help diagnose or monitor conditions like vasculitis or other autoimmune diseases.
["This test helps identify immune system responses linked to certain inflammatory or autoimmune conditions."]
Key facts at a glance
- LOINC
- 74281-7
- Short code
- M TB IFN-g+spot Pnl Bld
- Synonyms
- M TB IFN-g+spot Pnl Bld
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test if you have symptoms of conditions such as vasculitis (inflammation of blood vessels), autoimmune diseases, or unexplained fevers. It may also be used to assess immune responses in certain infections or inflammatory processes.
What Does the Test Involve?
A blood sample is taken from a vein, usually in your arm. The sample is then sent to a lab for analysis to measure the concentration of MPO antibodies in your serum.
What Should You Expect Before or After the Test?
No special preparation is usually needed. You may feel slight discomfort during the blood draw, but it typically resolves quickly. Avoid strenuous activity or eating heavy meals before the test if instructed by your provider.
What Are the Possible Results?
Results are reported as a quantitative measurement of antibody concentration. Higher levels may suggest an immune response to MPO, which could be associated with certain inflammatory or autoimmune conditions. Your results will be interpreted by your healthcare provider in the context of your overall health and symptoms.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: This test can be useful in diagnosing or monitoring conditions like granulomatosis with polyangiitis (formerly known as Wegener’s granulomatosis) or other vasculitides, where MPO antibodies are often elevated. It may also be part of broader evaluations for autoimmune diseases or immune-mediated inflammatory conditions. Results help guide treatment decisions and assess disease activity.
Short name
MPO Antibody Test
Frequently asked questions
What does an elevated MPO antibody level mean?
How often should I get this test?
Can lifestyle changes affect my test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy