Mass concentration of anti-Citrullinated Protein Antibody (anti-CCP) in serum

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like joint pain, swelling, or stiffness—especially if these symptoms persist for more than a few weeks. It can also be used to monitor disease activity or check for early signs of rheumatoid arthritis in people with other autoimmune conditions or unexplained joint issues.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw a blood sample. The test is quick and usually done in a doctor’s office or lab. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

High levels of anti-CCP antibodies are strongly associated with rheumatoid arthritis, but they can also appear in other autoimmune diseases. A positive result suggests a higher likelihood of rheumatoid arthritis, but it doesn’t confirm the diagnosis alone. Your doctor will consider other test results and symptoms to make a full assessment.

Common Reasons for Testing

This test is often used to screen for rheumatoid arthritis, especially in people with early symptoms or those at higher risk. It can also help track disease progression or response to treatment over time.