Methylmalonic Acid (MMA) in Serum/Plasma

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, weakness, neurological issues (such as numbness or tingling), or if they suspect a metabolic disorder. It’s often used alongside other tests to check for vitamin deficiencies or genetic conditions that disrupt normal metabolism.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours before your blood is drawn. Your doctor will explain any specific instructions for your situation.

What the Test Results Mean

Results are compared to a range of what’s considered normal for healthy adults. Elevated levels may indicate conditions like vitamin B12 deficiency, methylmalonic aciduria (a rare genetic disorder), or other metabolic issues. Low levels might suggest folate deficiency or other underlying problems.

Common Conditions Linked to MMA Levels

High MMA levels are often linked to vitamin B12 or folate deficiencies, which can cause anemia, nerve damage, or developmental delays in children. It can also be associated with inherited metabolic disorders or certain types of kidney disease.