Methionine Adenosyltransferase I (MAT1) Activity in Serum
This test measures the activity level of methionine adenosyltransferase I (MAT1), an enzyme involved in methionine metabolism. It may be used to assess liver function or detect certain genetic conditions.
["MAT1 activity helps evaluate how well your liver processes methionine, a key amino acid."]
Key facts at a glance
- LOINC
- 48175-4
- Short code
- MTB katG+inhA INH h res mut Islt/Spm Ql
- Synonyms
- MTB katG+inhA INH h res mut Islt/Spm Ql
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may order this test if you have symptoms or conditions linked to liver disease, genetic disorders affecting methionine metabolism, or if they suspect an inherited enzyme deficiency. It could also be part of a broader evaluation for conditions like homocystinuria or liver dysfunction.
What to Expect Before the Test
No special preparation is typically needed. You may have a blood sample drawn from a vein in your arm. If you’re on medications, let your provider know—some may affect test results.
What the Results Mean
Results are interpreted by your healthcare provider based on your medical history and symptoms. Abnormal levels might indicate liver issues, genetic disorders, or other metabolic problems. Your provider will discuss findings with you.
Common Conditions Linked to MAT1 Activity
Low MAT1 activity may be associated with liver diseases, certain genetic disorders (like MAT deficiency), or conditions affecting methionine metabolism. High levels could rarely suggest other metabolic imbalances.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Methionine adenosyltransferase I (MAT1) is a critical enzyme in the liver that converts S-adenosylhomocysteine back to methionine, a vital amino acid for protein synthesis and metabolism. Dysfunction in MAT1 can disrupt these processes, potentially leading to liver damage, neurological issues, or metabolic disorders. Your provider may use this test to diagnose or monitor conditions affecting methionine metabolism or liver health.
Short name
MAT1 Activity
Frequently asked questions
What causes abnormal MAT1 activity levels?
How is MAT1 activity tested?
Can diet or medications affect MAT1 test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy