Skip to content

Methylmalonic Acid (MMA) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid, a breakdown product of certain amino acids, in your blood. It helps identify conditions affecting metabolism, especially in vitamin B12 or folate deficiencies.

Quick summary

["Methylmalonic acid levels can signal metabolic disorders or vitamin deficiencies that may require medical attention."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105760-3
Short code
MTB mabA ethionamide res mut Islt/Spm Ql
Synonyms
MTB mabA ethionamide res mut Islt/Spm Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, weakness, or neurological issues. It’s also used to monitor conditions such as vitamin B12 deficiency, certain inherited metabolic disorders, or kidney disease.

What Does a High or Low Level Mean?

Elevated MMA levels may suggest metabolic disorders, vitamin deficiencies, or kidney problems. Low levels are less common but can sometimes indicate underlying health concerns that need evaluation.

How Is the Test Performed?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab for analysis using a specialized method to measure MMA concentration.

What Are Common Causes?

Conditions like vitamin B12 or folate deficiency, certain genetic metabolic disorders, or kidney disease can affect MMA levels. Rarely, other factors like liver disease or certain medications may play a role.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MMA Blood Test

Frequently asked questions

What if My Test Results Are Abnormal?
If your MMA levels are outside the expected range, your doctor may recommend further testing, such as checking vitamin B12 and folate levels, or additional genetic evaluations if a metabolic disorder is suspected.
Do I Need to Prepare for This Test?
No special preparation is usually needed, but avoid heavy meals before the blood draw. If you’re on medications, inform your healthcare provider beforehand.
How Long Will Results Take?
Results are typically available within 1 to 3 business days, depending on your lab’s processing time. Your doctor will discuss the findings with you.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy