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Methylmalonic Acid (MMA) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid, a breakdown product of certain amino acids in your body. It helps identify conditions affecting metabolism, such as vitamin B12 or folate deficiencies.

Quick summary

["Methylmalonic acid levels can signal metabolic disorders that may require vitamin or dietary adjustments."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105761-1
Short code
Mtb mabA INH hl res mut Islt/Spm
Synonyms
Mtb mabA INH hl res mut Islt/Spm
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like fatigue, weakness, or neurological issues that could be linked to metabolic disorders. It’s also used to monitor conditions like vitamin B12 deficiency or inherited metabolic diseases.

What Does the Result Mean?

Elevated levels may indicate vitamin deficiencies, genetic disorders, or other metabolic issues. Lower-than-expected levels might suggest rare genetic conditions or kidney problems. Your doctor will interpret results in the context of your symptoms and other tests.

Common Conditions Linked to MMA Levels

High MMA levels are often seen in vitamin B12 or folate deficiencies, certain inherited metabolic diseases (like methylmalonic aciduria), or kidney disorders. Low levels are less common but may relate to specific genetic conditions or rare metabolic errors.

What Can Affect This Test?

Factors like recent illness, certain medications (e.g., some antibiotics or diuretics), or dietary changes can influence MMA levels. Avoiding certain foods (like high-protein diets) for a few days before testing may help stabilize results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MMA Level

Frequently asked questions

What Are My Next Steps If My Test Result Is Abnormal?
If your MMA level is elevated, your doctor may recommend additional tests, such as vitamin B12 or folate levels, genetic testing, or further metabolic evaluations. Follow-up may include dietary changes, supplements, or monitoring for symptoms of underlying conditions.
How Often Should I Get This Test?
The frequency depends on your health condition. If you have a known metabolic disorder, your doctor may schedule regular tests. For routine checks, this test is usually not part of standard annual exams unless symptoms arise.
Can I Prepare for This Test at Home?
Yes! Avoid high-protein foods for 24–48 hours before testing, as they may temporarily raise MMA levels. Stay hydrated, but check with your lab for specific instructions, as some tests require fasting or special diet restrictions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy