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Serum or Plasma Creatinine Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function by measuring waste in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105762-9
Short code
Mtb oxyR-ahpC INH hl res mut Islt/Spm
Synonyms
Mtb oxyR-ahpC INH hl res mut Islt/Spm
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your kidneys normally filter waste products, including creatinine, from your blood. High levels may indicate kidney problems, while low levels could suggest dehydration or muscle breakdown. This test is often used alongside other measures to monitor kidney health, especially in people with risk factors like diabetes or high blood pressure.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw (serum/plasma) or, less commonly, a urine sample (though the slug indicates serum/plasma). Avoid strenuous activity or heavy meals 12 hours before if blood is drawn. If you’re on a low-protein diet, discuss it with your doctor, as it may affect results.

What the Results Mean

Results are compared to a reference range based on age, sex, and muscle mass. Elevated levels may signal kidney disease, while persistently low levels might warrant further investigation for conditions like muscle disorders or dehydration.

Common Causes of Abnormal Results

High creatinine levels can result from kidney disease, dehydration, or conditions that increase muscle breakdown (e.g., severe illness). Low levels may occur with dehydration, malnutrition, or certain medications. Always discuss results with your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine is a critical marker for kidney function. It reflects how well your kidneys remove waste from blood. Chronic kidney disease (CKD) often shows early signs with elevated creatinine, so regular monitoring is essential for people at risk. This test is also used to guide dialysis timing or adjust medications like lithium or contrast dyes that affect kidney function.

Short name

Creatinine

Frequently asked questions

Will I need to prepare for this test?
No special preparation is required, but avoid heavy meals or strenuous activity 12 hours before if a blood sample is taken. If you’re unsure, ask your doctor or lab technician.
Can diet affect my creatinine test results?
Yes, a low-protein diet may lower creatinine levels, while high-protein intake could raise them. If you’re on a restricted diet, inform your doctor before the test.
What if my results are outside the normal range?
Your doctor will interpret results in context of your health, other tests, and symptoms. High levels may signal kidney issues, while low levels could indicate dehydration or muscle problems. Follow-up may include more tests or adjustments to treatment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy