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Methylmalonic Acid, Serum or Plasma (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid (MMA) in your blood. MMA is a substance produced when certain amino acids break down, and high levels may signal underlying health issues.

Quick summary

["High MMA can indicate vitamin deficiencies or genetic disorders; low levels may suggest other metabolic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72864-2
Short code
MTB rpsL+rrs AMG res mut Islt/Spm Ql
Synonyms
MTB rpsL+rrs AMG res mut Islt/Spm Ql
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, muscle weakness, or neurological problems. It’s also used to monitor conditions such as vitamin B12 deficiency or inherited metabolic disorders.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if instructed by your healthcare provider. Bring any medications you’re taking to your appointment.

What the Results Mean

Results are compared to a reference range specific to your lab. Elevated levels may require further testing, such as vitamin B12 or folate checks, to identify the cause.

Common Causes of Abnormal Results

High MMA levels can stem from vitamin deficiencies, kidney disease, or genetic disorders like methylmalonic aciduria. Low levels are less common but may relate to certain metabolic syndromes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MMA Blood Test

Frequently asked questions

What does a high MMA level usually mean?
A high MMA level often suggests a vitamin deficiency (like B12 or folate), kidney problems, or a genetic metabolic disorder. Your doctor will guide further steps based on your full medical picture.
Can diet affect MMA levels?
Diet alone rarely changes MMA levels significantly, but certain metabolic disorders may require specific diets. Your doctor will work with you to address underlying causes.
Is this test painful?
The test involves a small needle inserted into your arm for blood collection. Most people experience minimal discomfort, similar to a standard blood draw. Local numbing cream may be used if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy