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Methylmalonic Acid (Serum or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid (MMA) in your blood. MMA is a substance produced when certain amino acids break down, and high levels may indicate problems with vitamin B12 or folate deficiency, certain genetic conditions, or kidney issues.

Quick summary

["High MMA levels may signal underlying health concerns that require further medical evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101952-0
Short code
MTTP Mut Anl Bld/T
Synonyms
MTTP Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, weakness, or neurological issues. It’s also used to monitor conditions such as vitamin B12 deficiency, pernicious anemia, or metabolic disorders like methylmalonic aciduria. Sometimes, it’s checked in people with unexplained anemia or kidney problems.

What Does the Test Involve?

A blood sample is taken from a vein in your arm. The blood is sent to a lab, where it’s analyzed to measure MMA levels using a specialized technique, often an immunoassay or enzymatic method.

What Are Possible Results?

Results are compared to a reference range, but exact values can vary by lab. High MMA levels may need further testing to determine the cause, such as checking vitamin B12 or folate levels.

What Does It Mean If My Levels Are High?

Elevated MMA can point to conditions like vitamin B12 deficiency, genetic disorders affecting metabolism, or kidney disease. Your doctor will discuss next steps, which may include additional tests or treatments.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MMA Blood Test

Frequently asked questions

What causes high MMA levels?
High MMA levels can result from vitamin B12 or folate deficiencies, certain genetic metabolic disorders (like methylmalonic aciduria), kidney disease, or conditions that disrupt normal amino acid metabolism.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your doctor will contact you once they’re ready.
Can I eat or drink before this test?
For most blood tests, you may eat and drink normally unless instructed otherwise. However, check with your doctor or lab for specific fasting requirements, as they may apply for certain conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy