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Methylmalonic Acid in Blood (Serum or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of methylmalonic acid (MMA) in your blood. MMA is a breakdown product of certain amino acids and can indicate metabolic issues.

Quick summary

["High MMA levels may signal vitamin deficiencies or genetic disorders affecting metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61111-1
Short code
Mt tRNA Mut Anl Bld/T
Synonyms
Mt tRNA Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, muscle weakness, or unexplained weight loss. It’s also used to monitor conditions such as vitamin B12 deficiency, mitochondrial disorders, or inherited metabolic diseases like methylmalonic aciduria.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if instructed. Bring any medications you’re taking, as some may affect results.

What the Test Involves

A blood sample will be drawn from a vein in your arm by a healthcare professional. The sample is sent to a lab for analysis using a specialized method to measure MMA levels accurately.

What the Results Mean

Results are compared to a reference range, though exact values can vary by lab. Elevated levels may point to metabolic disorders, while low levels could suggest vitamin deficiencies or other underlying conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Highlights of MMA Levels

Short name

MMA Blood Test

Frequently asked questions

What causes elevated MMA levels?
Elevated MMA levels are often linked to vitamin B12 or folate deficiencies, certain genetic disorders (like methylmalonic aciduria), or conditions affecting metabolism. Rarely, it may also appear in people with kidney disease or during pregnancy.
What causes low MMA levels?
Low MMA levels are less common but may occur in people with severe vitamin B12 deficiency or certain mitochondrial disorders. Some medications or liver/kidney issues could also influence results.
How often should I get this test?
Your doctor will determine the frequency based on your health status, symptoms, or treatment plan. Follow-up tests may be needed if initial results are abnormal or if you’re managing a known metabolic condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy