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Methylmalonic Acid in Blood (Mass Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of methylmalonic acid (MMA) in your blood. MMA is a substance produced when certain amino acids break down, and high levels may signal underlying health concerns.

Quick summary

["High MMA levels can indicate vitamin B12 or folate deficiencies or metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
81627-2
Short code
MTX-PG2 RBC-sCnc
Synonyms
MTX-PG2 RBC-sCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, numbness, weakness, or neurological issues. It’s also used to check for conditions like vitamin deficiencies, mitochondrial disorders, or inherited metabolic diseases.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if instructed by your doctor. Bring your lab slip and any medications you’re currently taking.

How the Test Works

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it’s analyzed using a specialized method to measure MMA levels accurately.

What the Results Mean

Results are compared to a reference range, but exact values depend on the lab. High levels may prompt further testing for vitamin deficiencies or metabolic disorders.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated MMA levels often point to vitamin B12 or folate deficiencies, which can cause anemia, nerve damage, or developmental issues in children. It may also signal genetic metabolic disorders like methylmalonic aciduria, requiring specialized care.

Short name

MMA Blood Test

Frequently asked questions

What causes MMA levels to be high?
High MMA levels can result from vitamin B12 or folate deficiencies, certain genetic disorders, kidney disease, or conditions that disrupt normal metabolism.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times.
Can I eat or drink before the test?
Follow your doctor’s instructions—some tests require fasting, while others allow light snacks or fluids. Always check with your lab or provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy