Skip to content

Cerebrospinal Fluid (CSF) Total Protein by Nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Protein levels can help diagnose conditions affecting the central nervous system.

Quick summary

["Protein in CSF may indicate inflammation, infection, or structural issues in the brain or spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22413-9
Short code
MuV Ab Titr CSF
Synonyms
MuV Ab Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, confusion, or neurological problems. It could also be done to investigate conditions such as meningitis, multiple sclerosis, or brain tumors.

What to Expect Before the Test

No special preparation is needed. You may have a small amount of fluid drawn from your lower back using a needle, similar to a spinal tap. You might feel a brief pinch, but it usually doesn’t cause significant discomfort.

What the Results Mean

Elevated protein levels in CSF might suggest inflammation, infection, or blood leakage into the fluid. Lower than normal levels could indicate certain neurological disorders or conditions affecting fluid production.

Common Conditions Affecting CSF Protein Levels

High protein levels can be linked to conditions like meningitis, encephalitis, or multiple sclerosis. Low protein levels may be seen in rare cases of hydrocephalus or certain genetic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Total

Frequently asked questions

How often is this test repeated?
The frequency depends on your symptoms and diagnosis. If your initial results are abnormal, your doctor may order this test again to monitor changes or confirm findings. Repeat tests are often done at intervals recommended by your healthcare provider.
What does it feel like to have the test done?
The procedure involves a small needle inserted into your lower back. You may feel a brief pinch, but it’s usually over quickly. Some people experience mild soreness afterward, but most find it tolerable.
Can I eat or drink before this test?
No special diet or restrictions apply. You can eat and drink normally before the test, as it doesn’t affect the accuracy of the results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy