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Quantitative Immunoassay for Anti-Nuclear Antibodies (ANA) in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies your body produces against components of your own cells, often used to help diagnose autoimmune conditions.

Quick summary

["Helps detect autoimmune diseases by checking for abnormal antibody presence in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108105-8
Short code
MuV RNA Bld Ql NAA+probe
Synonyms
MuV RNA Bld Ql NAA+probe
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is an ANA Test Used For?

An ANA test helps doctors identify whether your symptoms—such as joint pain, fatigue, or rash—might be linked to an autoimmune disease. It’s often the first step in diagnosing conditions like lupus, rheumatoid arthritis, or other connective tissue disorders.

How Is the Test Performed?

A small blood sample is drawn from your arm. The blood is then tested in a lab using an immunoassay method to detect and measure specific antibodies against nuclear components in your cells.

What Might Abnormal Results Indicate?

Higher-than-normal levels of ANA may suggest an autoimmune condition, though not all positive results mean you have one. Other factors, like age, sex, or certain medications, can also influence results.

When Might You Need This Test?

Your doctor may recommend an ANA test if you have symptoms like persistent fatigue, unexplained joint pain, or a rash, especially if they suspect an autoimmune disease. It’s also sometimes used as a screening tool for conditions like lupus or scleroderma.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

While a positive ANA test increases the likelihood of an autoimmune disorder, it’s not definitive. Many healthy people test positive, and some autoimmune diseases may not show ANA antibodies. Results should be interpreted alongside clinical symptoms, other tests, and patient history to guide diagnosis and treatment.

Short name

ANA Quant

Frequently asked questions

Why did my doctor order this test?
Your doctor may have suspected an autoimmune condition based on your symptoms, such as persistent fatigue, joint pain, or a rash. This test helps rule out or confirm whether your body is producing abnormal antibodies that could be causing these issues.
What does a positive ANA test mean?
A positive ANA test means your blood contains antibodies against nuclear components in your cells. This doesn’t always mean you have an autoimmune disease—many healthy people test positive. Your doctor will consider your symptoms, other test results, and medical history to determine next steps.
Can lifestyle changes affect ANA test results?
While certain medications (like hydroxychloroquine) or infections can temporarily alter ANA levels, lifestyle factors like diet or stress do not directly impact this test. Your doctor will discuss any medications or conditions that might influence your results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy