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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein levels and kidney function.

Quick summary

["Your blood protein levels can signal kidney health or other health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31506-9
Short code
MuV V Ab CSF-aCnc
Synonyms
MuV V Ab CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Matters

Protein is essential for many bodily functions, including maintaining fluid balance, supporting immune function, and repairing tissues. Low or high protein levels can indicate health issues like kidney disease, malnutrition, or liver problems.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Your results will show the total protein concentration in your blood. While reference ranges vary by lab, abnormal levels may prompt further testing for conditions like proteinuria (protein in urine) or hypoalbuminemia (low albumin).

Common Conditions Linked to Protein Levels

High protein levels might suggest dehydration, multiple myeloma (a blood cancer), or severe burns. Low levels could signal kidney disease, liver disease, or malnutrition. Always discuss results with your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How often do I need this test?
Your doctor may order this test periodically if you have kidney disease, liver issues, or other conditions affecting protein metabolism. Some routine check-ups may also include it.
Can diet affect my protein test results?
Yes, high-protein diets or certain medical conditions (like kidney disease) can influence results. Avoid extreme dietary changes before testing unless advised by your provider.
What if my results are outside the normal range?
If your results are abnormal, your doctor will likely order additional tests or evaluations to determine the cause. Follow their guidance for next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy