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Serum or Plasma Creatinine Concentration (Standard Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle breakdown, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function by evaluating how well your kidneys remove waste from your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
78188-0
Short code
MV lat ann s-prime Vmax TDI
Synonyms
MV lat ann s-prime Vmax TDI
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-tissue-doppler
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle metabolism and is normally filtered out by your kidneys. High levels can indicate poor kidney function, while low levels might suggest overhydration or muscle loss. This test is often used alongside other kidney function tests to diagnose or monitor conditions like chronic kidney disease.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw (serum or plasma) or, in some cases, a urine sample (though creatinine urine tests are less common for this specific measurement). If you’re on a low-protein diet, discuss it with your healthcare provider, as it may affect results.

What the Results Mean

Results are typically reported in units of mass concentration (e.g., milligrams per deciliter). While exact reference ranges vary by lab, higher-than-normal levels may signal kidney problems, while very low levels could raise concerns about hydration or muscle mass.

Common Conditions Monitored

This test is frequently used to monitor kidney health in conditions like diabetes, hypertension, or chronic kidney disease. It can also help assess kidney function before surgeries or during treatments that may affect kidney function.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated creatinine levels often indicate reduced kidney function, as the kidneys struggle to filter waste properly. Over time, this can lead to kidney damage or failure. Conversely, very low levels may suggest conditions like severe dehydration, muscle atrophy, or certain metabolic disorders. Your healthcare provider will interpret results in the context of your overall health and other tests.

Short name

Creatinine Level

Frequently asked questions

What causes creatinine levels to be higher than usual?
Several factors can increase creatinine levels, including kidney disease, dehydration, high muscle mass, certain medications (like contrast dyes used in imaging), or conditions that slow blood flow to the kidneys. Chronic kidney disease is the most common reason for elevated creatinine.
What if my creatinine level is lower than expected?
Low creatinine levels can occur due to dehydration, low muscle mass, or certain liver or muscle disorders. It’s important to discuss your results with your doctor, as they may also consider other factors like diet or medications that could affect the test.
How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and other conditions. For example, people with kidney disease may need regular monitoring, while others with no kidney issues may only need it occasionally or as needed.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy