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Serum/Plasma Mass Concentration of Alpha-1 Antitrypsin (A1AT)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect lungs and other tissues from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and other chronic conditions linked to protein imbalances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
81396-4
Short code
MV med ann a-prime Vmax TDI
Synonyms
MV med ann a-prime Vmax TDI
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-tissue-doppler
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms of lung disease (such as chronic cough, wheezing, or shortness of breath), a family history of Alpha-1 Antitrypsin deficiency, or if you have conditions like cirrhosis or chronic obstructive pulmonary disease (COPD). It may also be used to monitor treatment or assess risk in certain inherited conditions.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from a vein in your arm. If you’re on blood thinners, inform your healthcare provider beforehand.

How the Test Results Are Used

Results help determine if you have low Alpha-1 Antitrypsin levels, which could indicate a genetic disorder. Your doctor will compare your results to standard ranges and discuss them with you based on your medical history and symptoms.

Common Conditions Linked to Low Levels

Low Alpha-1 Antitrypsin levels are most strongly associated with **Alpha-1 Antitrypsin Deficiency**, a genetic condition that increases the risk of lung diseases (like emphysema) and liver disease. Other conditions may also be evaluated with this test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Alpha-1 Antitrypsin Deficiency

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

What does a low result mean?
A low result suggests you may have Alpha-1 Antitrypsin Deficiency, which can lead to lung damage over time. Your doctor will assess whether further testing or treatment is needed based on your symptoms and risk factors.
What does a normal result mean?
A normal result means your Alpha-1 Antitrypsin levels are within expected ranges, but genetic testing may still be recommended if you have a family history of the condition.
Could my results change over time?
Yes, levels can fluctuate slightly due to factors like inflammation, infections, or medications. If your doctor suspects a chronic condition, they may order follow-up tests to monitor changes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy