Molecular Detection of *Mycobacterium tuberculosis* DNA by Nucleic Acid Amplification Probe

How the Test Works

A small sample of your bodily fluid (such as sputum, blood, or other secretions) is collected and tested for the presence of *Mycobacterium tuberculosis* DNA. A specialized probe detects this genetic material using a highly sensitive nucleic acid amplification technique, often called NAAT (nucleic acid amplification test).

What to Expect Before the Test

You may be asked to follow specific instructions, such as spitting into a cup (for sputum samples) or providing a blood or other fluid sample, depending on your clinical situation. Some tests require you to fast or avoid certain medications before the procedure.

Common Specimens Used

The test can use different types of specimens, including sputum (from coughing), blood, or other bodily fluids like cerebrospinal fluid (if TB meningitis is suspected). The type of specimen depends on your symptoms and medical history.

When This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of TB (such as persistent cough, fever, weight loss, or chest pain), a history of TB exposure, or if you live or travel in areas with higher TB rates. It is also used to confirm TB diagnosis in people with positive TB skin tests or other initial screening results.