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Mycobacterium RNA Detection by Probe-Based Assay (Specimen: Stool)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from *Mycobacterium tuberculosis* or other mycobacteria in your stool, often used to diagnose gastrointestinal tuberculosis or atypical mycobacterial infections.

Quick summary

["Helps identify possible tuberculosis or other mycobacterial infections in the digestive tract."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43854-9
Short code
Mycobacterium rRNA Spec Ql Probe
Synonyms
Mycobacterium rRNA Spec Ql Probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like persistent diarrhea, unexplained weight loss, or abdominal pain, especially if you’ve been exposed to tuberculosis or have a weakened immune system. It’s also used in research or specialized diagnostic settings for gastrointestinal mycobacterial infections.

How the Test Works

A small sample of your stool is collected and analyzed using a probe-based molecular method. This detects genetic material (RNA) from mycobacteria, which helps confirm the presence of these bacteria without growing them in a lab.

Sample Collection and Preparation

You’ll need to provide a fresh stool sample, ideally collected in a sterile container. Follow your provider’s instructions to ensure the sample is handled properly to preserve accuracy.

What to Expect During Testing

The test is typically processed in a specialized lab. Results may take several days, depending on lab capacity. You’ll receive a report detailing whether mycobacterial RNA was detected or not.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Stool Mycobacterium RNA Probe Test

Frequently asked questions

What Does a Positive Result Mean?
A positive result indicates the presence of mycobacterial RNA in your stool, which may mean you have an infection. Your provider will discuss next steps, such as further testing or treatment options tailored to your symptoms and risk factors.
What Does a Negative Result Mean?
A negative result means no detectable mycobacterial RNA in this sample. However, it doesn’t rule out infection entirely—other tests or samples may be needed. If you have ongoing symptoms, consult your provider for additional evaluation.
How Often Should This Test Be Repeated?
This test is usually performed once unless your symptoms persist or your provider recommends retesting. If you’re part of a research study or have a suspected chronic infection, follow your provider’s guidance on repeat testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy