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Mycobacterium tuberculosis Antigen Detection (in Specimen)

Published: August 9, 2026Updated: August 16, 2026

This test detects specific antigens from *Mycobacterium tuberculosis*, the bacterium responsible for tuberculosis (TB). It helps identify active TB infection in your body.

Quick summary

["This test can help diagnose active TB by detecting bacteria-related proteins in your specimen."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40699-1
Short code
Mycobacterium Spec
Synonyms
Mycobacterium Spec
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test analyzes a sample of your bodily fluid (such as blood, urine, or other fluids) for the presence of *Mycobacterium tuberculosis* antigens. These antigens are proteins released by the bacteria during active infection. The test uses a sensitive detection method to identify these proteins, which can confirm or help rule out TB.

What to Expect Before the Test

No special preparation is needed for this test. You may be asked to provide a sample (e.g., urine, blood, or other fluid) depending on your clinical situation. If you’re unsure about the type of specimen, discuss it with your healthcare provider.

Common Uses of This Test

This test is primarily used to diagnose **active tuberculosis (TB)** in people who have symptoms like persistent cough, fever, weight loss, or chest pain. It may also be used in screening or monitoring for TB in high-risk groups (e.g., immunocompromised individuals, healthcare workers).

Potential Limitations

While this test is highly sensitive, it may not detect all cases of TB, especially in early or latent stages. False negatives can occur if the infection is very recent or if the specimen is not collected properly. Results should always be interpreted by a healthcare provider in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

TB Antigen Test

Frequently asked questions

Why might my healthcare provider order this test?
Your provider may recommend this test if you have symptoms of TB, such as persistent cough, fever, or weight loss, or if you’ve been exposed to TB. It helps confirm whether the illness is caused by *Mycobacterium tuberculosis* and guides treatment decisions.
What does a positive result mean?
A positive result means the test detected antigens from *Mycobacterium tuberculosis*, strongly suggesting active TB. This requires further evaluation (e.g., culture, imaging) and immediate medical treatment to prevent spread and complications.
What if I have a negative result but still suspect TB?
A negative result means the test did not detect TB antigens in your sample. However, TB can sometimes be hard to diagnose, especially in early stages. Your provider may recommend additional tests (e.g., sputum culture, chest X-ray) or repeat the test if symptoms persist.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy