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Mycoplasma pneumoniae Antibody, Qualitative (Serum/Plasma) by Nucleic Acid Amplification Test

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to *Mycoplasma pneumoniae*, a bacteria sometimes linked to respiratory infections like pneumonia or bronchitis. It helps diagnose whether your immune system has responded to an infection caused by this organism.

Quick summary

["This test may be used if you’ve had symptoms of a respiratory infection and testing for other causes hasn’t confirmed the diagnosis."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23298-3
Short code
Mycoplasma Ag Spec Ql IF
Synonyms
Mycoplasma Ag Spec Ql IF
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’ve had symptoms like cough, fever, or chest pain for weeks, especially if other tests (like a chest X-ray or culture) didn’t clearly identify the cause. It’s often used in cases where *Mycoplasma pneumoniae* is suspected but not definitively proven.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample (usually drawn from your arm) in a serum or plasma tube. The test analyzes a small amount of your blood for antibodies against *Mycoplasma pneumoniae* using a sensitive nucleic acid amplification method.

What the Test Results Mean

A positive result means your body has produced antibodies against *Mycoplasma pneumoniae*, suggesting past or recent infection. A negative result means no detectable antibodies were found, though this doesn’t always rule out infection if testing was done too early.

Common Causes of False Results

False positives or negatives can occur due to timing (e.g., testing too soon after infection) or other infections that trigger similar immune responses. Your provider will consider clinical symptoms and other test results when interpreting the result.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Role in Diagnosis and Management

Short name

Mycoplasma pneumoniae Antibody (Qualitative)

Frequently asked questions

Can this test help me get a diagnosis?
Yes, but it’s often used alongside other tests. Since antibodies take time to develop after infection, a negative result may not mean you don’t have an active *Mycoplasma pneumoniae* infection. Your provider will use the test result in combination with your symptoms, medical history, and other tests to guide treatment.
What if my test is positive?
A positive result suggests *Mycoplasma pneumoniae* was likely the cause of your symptoms. Your provider may recommend antibiotics (like azithromycin) to treat the infection. Follow-up testing or observation may be needed to confirm improvement.
How soon after infection should I get tested?
Ideally, testing should be done 2–4 weeks after symptoms begin, as antibodies peak during this time. If you’re tested earlier, you may get a negative result even if you’re infected. Your provider will determine the best timing based on your symptoms and clinical needs.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy