Mycoplasma species detection (serum/plasma)

What This Test Measures

Mycoplasma species are bacteria that lack a cell wall, making them difficult to culture. Instead, this test detects antibodies (immune proteins) your body produces in response to exposure. The presence of these antibodies suggests prior infection or exposure, though they do not confirm an active infection at the time of testing.

Why It Might Be Ordered

Doctors may order this test if you have symptoms like chronic fatigue, joint pain, or unexplained autoimmune reactions. It can also be part of a broader evaluation for conditions like chronic fatigue syndrome, fibromyalgia, or certain connective tissue disorders where Mycoplasma exposure is suspected.

How the Test Works

The test uses a blood sample (either serum or plasma) to detect specific antibodies against Mycoplasma species. These antibodies are found in your bloodstream if your immune system has encountered these bacteria. The test does not measure live bacteria or active infection directly; it only reflects past exposure.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw at your doctor’s office or lab. If you’re on blood-thinning medications, let your provider know before the test.