Myelin Basic Protein (MBP) in Cerebrospinal Fluid (CSF)

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like numbness, weakness, vision changes, or other neurological issues that could suggest nerve damage or inflammation in the central nervous system. It may also be used to monitor disease progression or response to treatment in certain conditions.

What to Expect Before the Test

You’ll have a lumbar puncture (spinal tap) to collect a small amount of cerebrospinal fluid (CSF) from your lower back. This procedure is usually done in a hospital setting with sedation. Avoid caffeine or alcohol for 24 hours before the test to help ensure accurate results.

What the Test Results Mean

Elevated levels of myelin basic protein in CSF may indicate demyelination (loss of the protective covering around nerves) due to conditions like multiple sclerosis, neuromyelitis optica, or other inflammatory diseases. However, results alone cannot diagnose a condition; they’re often used alongside other tests and clinical findings.

Common Conditions Monitored

This test is commonly used to diagnose or monitor multiple sclerosis, neuromyelitis optica spectrum disorder, and other demyelinating or inflammatory diseases of the central nervous system. It may also help assess the severity of nerve damage or guide treatment decisions.