Myelin Basic Protein (MBP) in Serum

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like numbness, weakness, vision problems, or balance issues that could suggest nerve damage. It’s sometimes used alongside other tests to diagnose conditions such as multiple sclerosis, neuromyelitis optica, or other inflammatory or demyelinating diseases of the central nervous system.

What Does a Positive or Abnormal Result Mean?

Elevated levels of myelin basic protein may indicate inflammation or damage to the myelin sheath, which insulates nerve fibers. While not definitive on its own, it can support a diagnosis of certain neurological conditions when combined with clinical findings and other tests.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then sent to a lab where it is processed to separate serum (the liquid part without blood cells) for testing. The lab uses a sensitive immunoassay method to detect and measure the myelin basic protein in your serum.

What Are Common Causes of Abnormal Results?

Abnormal results may occur due to conditions affecting the central nervous system, such as multiple sclerosis, neuromyelitis optica, or other inflammatory or demyelinating diseases. It can also be influenced by other factors like recent trauma, infections, or medications that affect nerve function.