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Myelin Basic Protein (MBP) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the levels of myelin basic protein, a key protein found in the myelin sheath that surrounds nerve fibers. It helps assess potential damage to the central nervous system.

Quick summary

["This test may help diagnose or monitor conditions affecting nerve insulation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58011-8
Short code
Myelin IgG Ser Ql IF
Synonyms
Myelin IgG Ser Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like numbness, weakness, or vision changes that could suggest nerve or brain damage. It may also be used to monitor conditions such as multiple sclerosis (MS) or other demyelinating diseases.

What Does the Test Involve?

A blood sample is taken from a vein, usually in your arm. The blood is then processed to separate serum or plasma, which is sent to a lab for testing using an immunoassay method to detect MBP.

What Do Results Mean?

Elevated levels of MBP may indicate damage to the myelin sheath, which could be associated with conditions like MS or other inflammatory or degenerative nerve diseases. However, results can vary, and interpretation depends on clinical context and other test results.

What Are Possible Conditions?

This test is often used to support a diagnosis of demyelinating diseases, including multiple sclerosis, but it is not definitive on its own. Other conditions, such as infections, tumors, or other neurological disorders, may also affect MBP levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Myelin Basic Protein (MBP) Test

Frequently asked questions

What does a high or low MBP level mean?
A high level of MBP may indicate myelin damage, which can be linked to conditions like multiple sclerosis or other neurological disorders. A low level does not necessarily mean there is no issue, as MBP is just one marker among many.
How often should I get this test?
Your healthcare provider will determine the frequency of testing based on your symptoms, diagnosis, and overall health. Regular monitoring may be recommended if you have a known condition affecting the nerves or brain.
Can lifestyle changes affect MBP levels?
While lifestyle factors like diet, exercise, and stress management can impact overall health, they may not directly influence MBP levels. This test is primarily focused on detecting specific protein changes in your blood or plasma.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy