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Myelin Basic Protein (MBP) in Cerebrospinal Fluid (CSF)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein found in the myelin sheaths of nerve fibers in your brain and spinal cord. It helps assess for demyelinating diseases, such as multiple sclerosis.

Quick summary

["A CSF MBP test may help diagnose nerve damage or inflammation in the central nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
8081-2
Short code
Myelin IgM Ser-aCnc
Synonyms
Myelin IgM Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like numbness, weakness, vision changes, or balance issues that could suggest a condition affecting your nerves or brain. It’s often used alongside other tests, such as MRI or nerve conduction studies, to support a diagnosis.

What Does the Test Measure?

Myelin Basic Protein (MBP) is a key component of the myelin sheath, which insulates nerve fibers. Elevated levels in the CSF may indicate damage or inflammation to these sheaths, often seen in conditions like multiple sclerosis or other demyelinating disorders.

How Is the Test Performed?

A small amount of cerebrospinal fluid (CSF) is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then sent to a lab for analysis using immunoassay methods to detect MBP.

What Are Common Results?

Results are typically reported as a concentration of MBP in the CSF. Elevated levels may suggest active nerve damage or inflammation, while normal results do not rule out other conditions. Interpretation depends on clinical context and other test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Myelin Basic Protein

Frequently asked questions

How long does it take to get my MBP test results?
Test results for MBP in CSF are typically available within 1–3 business days, depending on lab processing times. Your doctor’s office will contact you once results are ready.
Can I eat or drink anything before this test?
No special preparations are needed for this test. However, inform your doctor about any medications or supplements you’re taking, as they may affect results.
Is the lumbar puncture procedure painful?
The procedure itself may cause mild discomfort or soreness at the injection site, but it’s generally well-tolerated. You may experience a slight headache afterward, which can be managed with rest and hydration.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy