Myelin Basic Protein (MBP) in Cerebrospinal Fluid (CSF)

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like numbness, weakness, vision changes, or other neurological issues that could suggest demyelination, such as multiple sclerosis (MS) or other inflammatory or degenerative nerve diseases. It is often done alongside other tests, like MRI or nerve conduction studies, to support diagnosis.

What Does a Positive Result Indicate?

Elevated levels of myelin basic protein in CSF can indicate active demyelination or inflammation in the central nervous system. While not definitive on its own, it may suggest conditions like multiple sclerosis, neuromyelitis optica spectrum disorder (NMOSD), or other demyelinating diseases.

Sample Collection and Preparation

A lumbar puncture (spinal tap) is typically performed to collect CSF. This procedure involves inserting a needle into the spinal canal to withdraw a small amount of fluid. The collected CSF is then tested for myelin basic protein levels using sensitive laboratory techniques.

What to Expect Before the Test

You may experience mild discomfort or soreness at the injection site after the procedure. Avoid strenuous activities for a few hours afterward to prevent complications. Inform your doctor about any medications you’re taking, especially blood thinners, as they may affect the procedure.