Myelodysplastic Neoplasm, Bone Marrow — Chromosome Analysis by Fluorescence In Situ Hybridization (FISH)
A bone marrow chromosome test used to identify genetic abnormalities associated with myelodysplastic neoplasms and related blood disorders.
This test examines chromosomes in bone marrow cells for changes that may support the evaluation of a myelodysplastic neoplasm.
Key facts at a glance
- LOINC
- 106783-4
- Short code
- Myelodysplast neo chom anly Bld/Mar FISH
- Synonyms
- Myelodysplast neo chom anly Bld/Mar FISH
- Category
- liver
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 10
- Ref high
- 40
- Critical range
- — – 500 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- fish
- CPT
- 84484
- SNOMED
- 302774002
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This is a cytogenetic test called fluorescence in situ hybridization, or FISH. It uses fluorescent probes to look for specific chromosome changes in cells collected from bone marrow.
Why might I need this test?
A hematologist may order it when anemia, abnormal blood counts, or other findings suggest a myelodysplastic neoplasm, leukemia, or another marrow disorder. It can help identify important chromosome abnormalities that may influence diagnosis, prognosis, or treatment planning.
How is the test performed?
A laboratory examines chromosomes in bone marrow cells using fluorescent DNA probes. The result reports whether the selected chromosome abnormalities are present or absent; FISH evaluates specific targeted abnormalities rather than every possible genetic change.
How do I prepare for the test?
FISH itself requires no special preparation, but it usually requires a bone marrow sample collected by a clinician. Follow the laboratory's instructions and ask whether local anesthetic, sedation, or other precautions are needed for the collection procedure.
Reference range
Adult: 10-40 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Detecting certain chromosome abnormalities may support a diagnosis of a myelodysplastic neoplasm or another myeloid disorder and can provide information about likely behavior and treatment options. A normal FISH result does not exclude these conditions because some relevant abnormalities are not included in the test. Results should be interpreted by a hematologist together with the blood counts, marrow findings, and other genetic testing.
Short name
Bone Marrow FISH for Myelodysplastic Neoplasm
Frequently asked questions
Is this the same as a routine blood test?
Does an abnormal result confirm myelodysplastic neoplasm?
Can this test show that treatment is needed?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy