Myeloid Neoplasm Chromosomal Analysis by Fluorescence In Situ Hybridization (FISH) on Bone Marrow Cells
This test examines genetic changes in white blood cells from your bone marrow to help diagnose or monitor conditions like leukemia or other myeloid blood disorders.
["Helps detect genetic abnormalities in blood cells that may indicate a blood cancer or other myeloid disorders."]
Key facts at a glance
- LOINC
- 94588-1
- Short code
- Myeloid neoplasm chr analy Bld/Mar MPSeq
- Synonyms
- Myeloid neoplasm chr analy Bld/Mar MPSeq
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 27
- Ref high
- 33
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- mate-pair-sequencing
- CPT
- 86038
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test uses fluorescent probes to identify specific genetic abnormalities (such as translocations, deletions, or amplifications) in myeloid cells. These probes bind to specific DNA sequences on chromosomes, allowing for visualization under a microscope. The presence of these genetic changes can help confirm a diagnosis or guide treatment decisions.
Why It’s Done
Your healthcare provider may recommend this test if you have symptoms of a blood disorder (such as fatigue, unexplained bruising, or frequent infections) or if you’ve been diagnosed with a suspected myeloid neoplasm (e.g., myelodysplastic syndromes, acute myeloid leukemia). It’s also used to monitor disease progression or response to treatment.
Sample Collection and Preparation
A small sample of bone marrow is typically collected during a procedure called a bone marrow biopsy. The sample is then processed to isolate myeloid cells, which are analyzed for genetic abnormalities using FISH techniques.
What to Expect Before the Test
You may receive local anesthesia at the biopsy site to minimize discomfort. Recovery is usually quick, but you may experience mild soreness or bruising. Avoid heavy lifting or strenuous activity for a few days afterward.
Reference range
Adult: 27-33 pgN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test plays a critical role in diagnosing and managing myeloid neoplasms by identifying genetic markers that influence disease behavior. Certain abnormalities may predict prognosis or guide treatment options, such as targeted therapies or supportive care. Early detection can improve outcomes and help tailor treatment plans to your specific needs.
Short name
Myeloid Neoplasm FISH on Bone Marrow
Frequently asked questions
What does a positive result mean?
Will this test be done if I have no symptoms?
How long will it take to get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy