Myeloperoxidase Antibody, Serum (IgG)

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions associated with autoimmune diseases, such as vasculitis (inflammation of blood vessels), certain types of arthritis, or other inflammatory disorders. It may also be used to monitor treatment responses or diagnose specific conditions like systemic lupus erythematosus (SLE) or other connective tissue diseases.

What the Test Involves

A blood sample is drawn from a vein, usually in your arm. The sample is then sent to a lab for analysis. The test looks for IgG antibodies that target myeloperoxidase, an enzyme involved in the immune system’s response to infections and inflammation.

What the Results Mean

Elevated levels of anti-myeloperoxidase antibodies may suggest an autoimmune condition affecting blood vessels or connective tissues. However, results alone do not diagnose a condition; they are used alongside other tests and clinical findings. Your doctor will interpret the results in the context of your symptoms and medical history.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions like primary antiphospholipid syndrome, certain types of vasculitis (such as microscopic polyangiitis or Churg-Strauss syndrome), and other autoimmune disorders that involve the immune system attacking healthy tissues.