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Cerebrospinal Fluid Protein by Nephelometry (Total Protein)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Protein levels can help diagnose or monitor conditions affecting the central nervous system.

Quick summary

["Protein in CSF may signal inflammation, infection, or other neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74922-6
Short code
N-Ac-L-Asp CSF-sCnc
Synonyms
N-Ac-L-Asp CSF-sCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, confusion, or signs of nerve or brain problems. It can also be part of a routine evaluation for conditions like multiple sclerosis, meningitis, or tumors.

What to Expect Before the Test

You’ll likely have a small needle inserted into your back to collect a sample of cerebrospinal fluid. This is usually done in a hospital or clinic setting. You may feel a brief pinch, but it’s generally quick and not painful.

What the Results Mean

Elevated protein levels in CSF might indicate inflammation, infection, or other neurological disorders. Lower-than-expected levels could suggest certain genetic or metabolic conditions. Your results will be interpreted by a healthcare provider based on your symptoms and medical history.

Common Conditions Monitored

This test helps diagnose or track conditions like multiple sclerosis, Guillain-Barré syndrome, meningitis, encephalitis, or brain tumors. It can also assess for conditions like subarachnoid hemorrhage or certain autoimmune diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Level

Frequently asked questions

What causes abnormal protein levels in CSF?
Abnormal protein levels in CSF can result from infections (like meningitis), inflammatory diseases (such as multiple sclerosis), tumors, or other neurological conditions. Sometimes, genetic or metabolic disorders may also affect protein levels.
How long does it take to get results?
Results are typically available within a few days to a week, depending on lab processing times. Your healthcare provider will discuss the findings with you during your follow-up visit.
Can diet or medications affect this test?
Diet or over-the-counter medications are unlikely to affect CSF protein levels. However, certain medications (like steroids) or conditions (like severe dehydration) might influence results, so always inform your provider of all medications or supplements you’re taking.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy