N-acetylgalactosamine-6-sulfatase activity (serum/plasma)
This test measures the activity of an enzyme called N-acetylgalactosamine-6-sulfatase, which helps break down certain sugars in your body. It is often used to diagnose metabolic conditions affecting how your body processes these sugars.
["This test helps identify genetic disorders linked to enzyme deficiencies."]
Key facts at a glance
- LOINC
- 24098-6
- Short code
- NAG6Sulfatase WBC-cCnt
- Synonyms
- NAG6Sulfatase WBC-cCnt
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 4.5
- Ref high
- 11
- Critical range
- 2 N/A – 30 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85004
- SNOMED
- 900000000000003002
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test if you have symptoms of a metabolic disorder, such as developmental delays, movement problems, or repeated infections. It may also be part of screening for inherited conditions like Mucopolysaccharidosis (MPS) types I and VI, where this enzyme is deficient.
What Does the Test Involve?
A blood sample is taken from a vein in your arm. The blood is then processed to separate the serum or plasma, where the enzyme activity is measured. The test checks how well the enzyme works in your body’s fluids.
What Are Common Results?
Results are typically reported as a ratio or relative activity level compared to a standard. Low enzyme activity suggests a possible metabolic disorder, while normal levels indicate no significant deficiency.
What Does It Mean If My Results Are Abnormal?
Abnormally low enzyme activity may indicate conditions like MPS I or VI, where the body cannot properly break down certain sugars. Further testing and genetic evaluation may be needed to confirm a diagnosis and guide treatment options.
Reference range
Adult: 4.5-11.0 x 10^9/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test plays a key role in diagnosing inherited metabolic disorders by identifying enzyme deficiencies. Early detection can lead to better management and support for affected individuals, helping them live healthier lives.
Short name
Nagase Enzyme Test
Frequently asked questions
Why might my doctor request this test?
How long does it take to get results from this test?
Can I eat or drink anything before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy