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Naproxen concentration in plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of naproxen, a nonsteroidal anti-inflammatory drug (NSAID), in your blood plasma. It helps your healthcare provider assess drug levels to ensure safe and effective dosing.

Quick summary

["This test helps monitor how much naproxen is in your system for proper treatment and safety."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73248-7
Short code
Naproxen ind plt IgM SerPl Ql FC
Synonyms
Naproxen ind plt IgM SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you’re taking naproxen (a medication like Aleve® or Naprosyn®) for conditions like arthritis, pain, or inflammation. It helps ensure your dose is appropriate and avoids potential side effects, such as stomach irritation or kidney issues.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your vein or arm for a blood draw. The process is quick and usually painless. If you’re on blood thinners or have a history of bleeding disorders, let your doctor know before the test.

What the Results Mean

Results show the concentration of naproxen in your plasma. While reference ranges vary by lab and medication form, your doctor will compare your result to your specific dose and health status to guide treatment. Abnormally high levels may indicate overdose or poor metabolism, while low levels might suggest insufficient absorption.

Potential Side Effects or Considerations

Naproxen is generally safe when taken as directed, but high levels in the blood can increase risks like stomach bleeding, kidney problems, or dizziness. If you experience nausea, vomiting, or unusual fatigue after taking naproxen, report it to your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Monitoring naproxen levels is critical for patients with kidney disease, liver issues, or those taking other medications that interact with NSAIDs. It also helps adjust doses in children, elderly patients, or those with reduced kidney function to prevent toxicity or underdosing.

Short name

Naproxen Level

Frequently asked questions

How often should I get this test?
Your doctor will determine the timing based on your naproxen dose, medical history, and how your body processes the medication. Typically, this test may be done during or shortly after starting therapy, then periodically if you’re on long-term use or have specific health risks.
What happens if my naproxen level is too high?
If levels are dangerously elevated, your doctor may adjust your dose, switch to a different medication, or monitor you more closely. Severe cases could require medical treatment to lower the drug levels safely.
Can I drink alcohol while taking naproxen?
Avoid alcohol while on naproxen, as it can increase stomach irritation and raise the risk of bleeding. Always follow your doctor’s advice about interactions with other substances, including over-the-counter medications.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy