Genetic analysis of NAT (N-acetyltransferase) gene allele frequency in whole blood
This test checks the genetic variation in your NAT gene, which influences how your body processes certain medications and toxins. It helps determine if you may have a different response to drugs like isoniazid (used for tuberculosis) or other substances.
["Understanding your NAT gene can help tailor medical treatment to your body’s unique chemistry."]
Key facts at a glance
- LOINC
- 101142-8
- Short code
- NAT2 gene allele Geno Bld/T
- Synonyms
- NAT2 gene allele Geno Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you’re at risk for certain side effects from medications that rely on NAT enzyme activity, such as tuberculosis treatments. It’s also sometimes used in research or genetic counseling to assess inherited traits.
What to Expect Before the Test
You’ll provide a small sample of whole blood, typically drawn from your arm. No special preparation is needed, but tell your provider if you’re taking medications that might affect blood clotting.
What the Results Mean
Results show the frequency of specific NAT gene variants in your DNA. These variants can affect how efficiently your body breaks down certain drugs or toxins. Your provider will interpret results in the context of your medical history and treatment needs.
Common Uses and Considerations
This test is primarily used for research, genetic counseling, or guiding treatment for conditions where NAT enzyme activity plays a role. It’s not a routine screening test for most people.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance: NAT gene variants can influence drug metabolism, potentially affecting how well a medication works or how your body tolerates it. For example, certain variants may lead to lower drug effectiveness or increased risk of side effects, especially with medications like isoniazid.
Short name
NAT Gene Allele Test
Frequently asked questions
Will this test affect my current medications?
How long will I need to wait for results?
Is this test covered by insurance?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy